The Male Menopause or Andropause, and its treatment with Testosterone Replacement therapy

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Diagnosis of Male Menopause (Andropause)

Symptoms attributed to the andropause in various studies.

YR. STUDY STARTED	1939³	1953⁴	1989⁵	1996⁶	1998¹	1999⁷	1999⁸
AUTHOR	Werner	Reiter	Carruthers	Carruthers	Tremblay	Heinemann	Morley
SCALE TITLE	Male Climacteric	IDUT	ACL	Web ACL	CAS	AMS	ADAM
RESPONSES	Yes/No	0-12	0,1,2,3,4	0,1,2,3,4	Yes/No	1,2,3,4,5	Yes/no
No. SUBJECTS	273	100	1,500	1,533	300	992	316
SYMPTOMS
Erectile Dysfunction	90	++	84	83	++	88	+++
Libido/sex drive/desire	81	++	82	87	++	84	+++
Fatigue/energy reduced	80	+	78	94	+	80	++
Depression	77	++	62	88	+	75	+
Anxiety/nervousness	91	++	++	85	+	69
Memory/concentration	76	+	42	90	+		+
Irritability/anger	80	+	57	85	+	72	+
Aches/pains joints	33		57	83		77
Sweating esp. night	18		50	63	+	66
Vasomotor/flushes	46		27		+
Ageing/older than years			43	55		59
Dry skin/thinning	30		40	63

Reference List

1. Tremblay RR,.Morales AJ. Canadian practice recommendations for screening, monitoring and treating men affected by andropause or partial androgen deficiency. Aging Male 1998;1:213-8.

2. Gooren LG. Quality-of-life issues in the aging male. Aging Male 2000;3:185-9.

3. Werner AA. The male climacteric:Report of two hundred and seventy-three cases. J.Am.Med.Ass. 1946;132:188-94.

4. Reiter, T. Testosterone Implantation: The method of choice for treatment of testosterone deficiency. Journal of the American Geriatrics Society 13, 1003-1012. 1965.

5. Carruthers M. A multifactorial approach to understanding andropause. J.Sexual and Reproductive Medicine 2001;1:69-74.

6. Carruthers M. Testosterone Revolution. Thorsons, London, 2001.

7. Heinemann LAJ, Zimmermann T, Vermeulen A, Thiel C, Hummel W. A new 'aging males' symptoms' (AMS) rating scale. Aging Male 1999;2:105-14.

8. Morley JE, Charlton E, Patrick P, Kaiser FE, Cadeau P, McCready D et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism 2000;49:1239-42.